Melanin-Concentrating Hormone and Sleep by S. R. Pandi-Perumal Pablo Torterolo & Jaime M. Monti

Author:S. R. Pandi-Perumal, Pablo Torterolo & Jaime M. Monti
Language: eng
Format: epub
Publisher: Springer International Publishing, Cham

2 Neural Structures and Neurotransmitter Systems Involved in the Generation and Maintenance of NREM Sleep

Neurons of the preoptic area and adjacent BFB constitute the sleep-inducing system (Szymusiak et al. 2007). Sleep active neurons of the preoptic area are mainly located in the ventrolateral preoptic area (VLPO). A majority of these neurons contain γ-aminobutyric acid (GABA) and galanin and project to brainstem and hypothalamic areas involved in the promotion of W including the DRN, LC, LDT/PPT, vPAG, and LH neurons. More recently, melanin-concentrating hormone (MCH) neurons located in the lateral hypothalamus and zona incerta have been proposed to participate also in the regulation of non-rapid-eye movement (NREM) sleep and REM sleep (Torterolo et al. 2011).

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